How Depression Affects the Mind and Body Is depression a mental disability? Yes. It impacts mental health and can affect physical health too. People with major depression might feel very tired, struggle to sleep, or have physical pain. Labeling it as a mental disability shows how it can lower the quality of life. In extreme cases, chronic depression may cause lasting mental health i... https://goodnesspsychiatryllc.com/major-depressive-disorder-a-disability/