Abstract The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein. an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed. which can dilate vessle and improve the drug penetration by in situ releasing nitric oxide (NO). https://www.nacrack.com/mega-pick-Legacy-Kelly-Green-Spear-Cool-Fit-Adjustable-Visor-White-quick-deal/